药物作用靶点取决于致病相关基因。例如一疾病的致病相关基因是X1,X2和X3,某治疗药物系针对致病基因X3为靶点,且为无活性的前药,在体内经过A→B→C途径代谢成活性形式,作用于靶点X3。不同患者用药效果截然不同。

给予致病基因为X3,但有变异的患者用药,结果是

A:致病基因不同,无效 B:针对作用靶点,效果良好 C:无此药的作用靶点,无效 D:不能代谢为活性形式,无效 E:基因变异影响药物结合靶点,药效不理想,剂量要调整

药物作用靶点取决于致病相关基因。例如一疾病的致病相关基因是X1,X2和X3,某治疗药物系针对致病基因X3为靶点,且为无活性的前药,在体内经过A→B→C途径代谢成活性形式,作用于靶点X3。不同患者用药效果截然不同。

给予致病基因为X3,且药酶基因A,B,C均无突变的患者,结果是

A:非致病基因,无效 B:正中作用靶点,效果良好 C:无效,非此药作用靶点 D:无效,缘于体内不能代谢 E:基因变异影响药物结合靶点,药效不理想

(一疾病的致病相关基因是X1,X2和X3,某一无活性的前药,在体内经过K→L→M途径代谢成活性形式,作用于致病基因靶点X3。不同患者用药效果有异)

致病基因为X3,但有变异的患者

A:使用无效 B:剂量要减少 C:剂量要酌增加 D:效果很理想 E:呈现中毒反应

(一疾病的致病相关基因是X1,X2和X3,某一无活性的前药,在体内经过K→L→M途径代谢成活性形式,作用于致病基因靶点X3。不同患者用药效果有异)

致病基因为X3,药物代谢酶基因L有变异的患者

A:使用无效 B:剂量要减少 C:剂量要酌增加 D:效果很理想 E:呈现中毒反应

(一疾病的致病相关基因是X1,X2和X3,某一无活性的前药,在体内经过K→L→M途径代谢成活性形式,作用于致病基因靶点X3。不同患者用药效果有异)

致病基因为X3,且药酶基因A,B,C均无突变的患者

A:使用无效 B:剂量要减少 C:剂量要酌增加 D:效果很理想 E:呈现中毒反应

In what way does free float differ from total float ?()

A:Free float is the amount of total float that does not affect the end date, whereas total float is the accumulated amount of free float. B:There is no difference-the two terms are functionally equivalent. C:Free float is the amount of time that a schedule activity can be delayed without delaying the early start of any immediately following schedule activities, whereas total float is concerned with delays that do not affect the project finish date. D:An activity's free float is calculated by subtracting its total float from the critical path's total float.

In what way does free float differ from total float

A:Free float is the amount of total float that does not affect the end date, whereas total float is the accumulated amount of free floa B:There is no difference-the two terms are functionally equivalen C:Free float is the amount of time that a schedule activity can be delayed without delaying the early start of any immediately following schedule activities, whereas total float is concerned with delays that do not affect the project finish dat D:An activity's free float is calculated by subtracting its total float from the critical path's total floa

类Test定义如下,将下列哪个方法插入行③处是不合法的    ① public class Test {    ②   public float Method(float a,float b) { }    ③    ④ }

A:public float Method(float a,float b,float c) { } B:public float Method(float c,float d){ } C:public int Method(int a,int b){ } D:private float Method(int a,int b,int c){ }

类Test定义如下,将下列哪个方法插入行③处是不合法的    ① public class Test {    ②   public float Method(float a,float b) { }    ③    ④ }

A:public float Method(float a,float b,float c) { } B:public float Method(float c,float d){ } C:public int Method(int a,int b){ } D:private float Method(int a,int b,int c){ }

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