Pregnant Women Warned About ACE1 Inhibitor

    1. Some of the most commonly used medicines for high blood pressure are drugs called ACE inhibitors. Doctors have given these drugs to patients for twenty-five years. A government study in the United Statesfound that the use almost doubled between 1995 and 2000.

    2. Doctors have known for years that women should not take ACE inhibitors during the last six months of pregnancy. The medicine can injure the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a New study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders2. The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.

    3. The researchers say they found no increased risk in women who took other blood pressure medicines during the first three months. Researchers atVanderbiltUniversityinTennesseeandBostonUniversitydid the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to women who took ACE inhibitors during the first three months of their pregnancies. Eighteen of the babies, or almost nine percent, had major disorders.

    4. ACE inhibitors are often given to patients with diabetes. But diabetes during pregnancy can result in birth defects. So the study did not include any women known to be diabetic5. ACE inhibitors suppress a protein called angiotensin-converting enzyme, or ACE. This enzyme produces a chemical in the body that makes blood passages narrow. The drugs increase the flow of blood so pressure is reduced.

    5. New drugs are tested on pregnant animals to see if they might cause birth defects in humans. But experts say these tests are not always dependable. The United States Food and Drug Administration6 helped pay for the study. The F. D. A. says women who might become pregnant should talk with their doctor about other ways to treat high blood pressure.

 

词汇:

pregnant /"pregnənt/ adj.怀孕的

warn /wɔːn/ vt.警告

inhibitor /ɪn"hɪbɪtə/n. 抑制剂

pregnancy /"pregnənsɪ/ n.怀孕

diabetes ( = diabetes mellitus) /,daɪə"biːtiːz/ n.糖尿病

diabetic /daɪə"betɪk/ adj.糖尿病的;n.糖尿病患者

suppress /sə"pres/ vt.抑制

protein /"prəʊtiːn/ n.蛋白(质)

dependable /dɪ"pendəb(ə)l/ adj.可靠的

 

注释:

1.ACE (angiotensin-converting enzyme):血管紧张肽转化酶

2.birth disorders:先天性疾病

3.The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.这项研究表明,与其他婴儿相比,这些婴儿在出生时患大病的可能性几乎是他们的三倍。problem在医学文献中常常用来指疾病。

4.New England Journal Medicine:《新英格兰医学杂志》。New England是美国东北六州(Maine, Vermont, New Hampshire, Massachusetts, Rhode Island Connecticut)的总称。

5.birth defect ( = congenital defect):先天性缺陷,先天性缺损

6.United States Food and Drug Administration (FDA):美国食品与药品管理局A that may cause our blood vessels to become more and more narrow

B for pregnant women to take during their last six months of pregnancies

C that their likelihood to suffer major problems is two times higher than other babies

D with their doctors about how to treat their problems

E because diabetes during pregnancy may sometimes lead to birth defects

F. though their mothers took ACE inhibitors during their first three months of pregnancies

ACE inhibitors are not recommended ____________.

A:A B:B C:C D:D E:E F:F

Pregnant Women Warned About ACE1 Inhibitor

    1. Some of the most commonly used medicines for high blood pressure are drugs called ACE inhibitors. Doctors have given these drugs to patients for twenty-five years. A government study in the United Statesfound that the use almost doubled between 1995 and 2000.

    2. Doctors have known for years that women should not take ACE inhibitors during the last six months of pregnancy. The medicine can injure the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a New study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders2. The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.

    3. The researchers say they found no increased risk in women who took other blood pressure medicines during the first three months. Researchers atVanderbiltUniversityinTennesseeandBostonUniversitydid the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to women who took ACE inhibitors during the first three months of their pregnancies. Eighteen of the babies, or almost nine percent, had major disorders.

    4. ACE inhibitors are often given to patients with diabetes. But diabetes during pregnancy can result in birth defects. So the study did not include any women known to be diabetic5. ACE inhibitors suppress a protein called angiotensin-converting enzyme, or ACE. This enzyme produces a chemical in the body that makes blood passages narrow. The drugs increase the flow of blood so pressure is reduced.

    5. New drugs are tested on pregnant animals to see if they might cause birth defects in humans. But experts say these tests are not always dependable. The United States Food and Drug Administration6 helped pay for the study. The F. D. A. says women who might become pregnant should talk with their doctor about other ways to treat high blood pressure.

 

词汇:

pregnant /"pregnənt/ adj.怀孕的

warn /wɔːn/ vt.警告

inhibitor /ɪn"hɪbɪtə/n. 抑制剂

pregnancy /"pregnənsɪ/ n.怀孕

diabetes ( = diabetes mellitus) /,daɪə"biːtiːz/ n.糖尿病

diabetic /daɪə"betɪk/ adj.糖尿病的;n.糖尿病患者

suppress /sə"pres/ vt.抑制

protein /"prəʊtiːn/ n.蛋白(质)

dependable /dɪ"pendəb(ə)l/ adj.可靠的

 

注释:

1.ACE (angiotensin-converting enzyme):血管紧张肽转化酶

2.birth disorders:先天性疾病

3.The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.这项研究表明,与其他婴儿相比,这些婴儿在出生时患大病的可能性几乎是他们的三倍。problem在医学文献中常常用来指疾病。

4.New England Journal Medicine:《新英格兰医学杂志》。New England是美国东北六州(Maine, Vermont, New Hampshire, Massachusetts, Rhode Island Connecticut)的总称。

5.birth defect ( = congenital defect):先天性缺陷,先天性缺损

6.United States Food and Drug Administration (FDA):美国食品与药品管理局A that may cause our blood vessels to become more and more narrow

B for pregnant women to take during their last six months of pregnancies

C that their likelihood to suffer major problems is two times higher than other babies

D with their doctors about how to treat their problems

E because diabetes during pregnancy may sometimes lead to birth defects

F. though their mothers took ACE inhibitors during their first three months of pregnancies

ACE is a risk factor to our body ____________.

A:A B:B C:C D:D E:E F:F

AT1受体拮抗药与ACE抑制药比较,不正确的是()

A:抗高血压和心力衰竭治疗时疗效相似 B:不能耐受ACE抑制药的咳嗽患者可改用AT1受体拮抗药 C:AT1拮抗药是阻断AngⅡ,因此作用比ACE抑制药更完全 D:AT1拮抗药缺乏ACE抑制药的缓激肽-NO途径的心血管保护作用 E:AT1受体拮抗药可抑制ACE,产生缓激肽等引起的咳嗽

定净交换功率控制方式的区域控制偏差(ACE)数学表达式为()。

A:ACE=△P B:ACE=10B△f C:ACE=10B△f+△P D:ACE=B△f

ACE是指

A:氨基氧化酶 B:血管紧张素转化酶 C:乙酰基转化酶 D:羟甲戊二酰辅酶 E:磷酸二酯酶

ACE是指

A:氨基氧化酶 B:血管紧张素转化酶 C:乙酰基转化酶 D:羟甲戊二酰辅酶 E:磷酸二酯酶

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